Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 161

Conference Videos 112

Conference Information 1

Year

2024 2

2023 16

2022 80

2021 54

2020 7

2019 19

2018 9

2017 7

2016 9

2015 9

2014 2

2013 7

2012 6

2011 1

2010 7

2009 20

2008 10

2007 4

2006 1

2003 2

open ︾

Keywords

prognosis 6

Alzheimer’s disease 4

DNA 3

Hepatocellular carcinoma 3

Neospora caninum 2

Drug discovery 2

E3 ubiquitin ligase 2

FGF21 2

GWAS 2

Polycyclic aromatic hydrocarbons 2

Protein 2

food security 2

hepatocellular carcinoma 2

resistance 2

β 1

-catenin 1

1 1

12 inches 1

1T/2H-MoS₂ 1

open ︾

Search scope:

排序： Display mode:

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredThere was basal expression of Shh and Fgf8 in the control group.Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesThe results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardialAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid Tbx1 protein Shh protein Fgf8 protein

HTML PDF Collect

The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolicDuring evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elementsBy contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparanFGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis.The significant divergence in structural elements and multiple functional specifications of FGF19, 21

Keywords： FGF19 FGF21 FGF23 FGFR metabolism endocrine Klotho

HTML PDF Collect

FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potentialIn this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin Dmetabolism, and the FGF23 related bone disease.

Keywords： fibroblast growth factor 23 FGF receptor phosphate metabolism Klotho bone disease

HTML PDF Collect

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting itsResults showed that FGF13 was lowly expressed in patients with AML and that its elevated expression wasUnivariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factorA prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice.

Keywords： acute myeloid leukemia FGF13 prognosis immune-related genes bone marrow niches

HTML PDF Collect

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2, Pages 221-237 doi: 10.1007/s11705-020-1927-8

Abstract: Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class ofaspects ranging from synthesis methods, property characterization to potential applications of ZIF-8.This review focuses on the recent development of ZIF-8 synthesis methods and its promising applicationsThe potential risks of using ZIF-8 for drug delivery are also summarized.

Keywords： zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery

HTML PDF Collect

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal

Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 72-76 doi: 10.1007/s11684-014-0347-x

Abstract: This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitisto establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis.Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISAusing Quantikine human total MMP-8 immunoassay kits.The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and

Keywords： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival

HTML PDF Collect

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2, Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract: Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccineBALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, andSerological analysis showed that recombinant protein vaccines induced higher levels of immunoglobulinThe percentage of IgG1 and IgG2a in the recombinant protein groups was higher than the other groups,and with a predominance of IgG1 over IgG2a, suggesting that recombinant protein vaccines elicited a Th2

Keywords： NcMIC3 NcMIC8 Neospora caninum vaccination

HTML PDF Collect

The Undersea Tunnel on Qingdao Metro Line 8

Weiguo He, Peng Liu

Engineering 2018, Volume 4, Issue 2, Pages 167-169 doi: 10.1016/j.eng.2018.03.012

HTML PDF Collect

Development of 8-inch Key Processes for Insulated-Gate Bipolar Transistor Article

Guoyou Liu,Rongjun Ding,Haihui Luo

Engineering 2015, Volume 1, Issue 3, Pages 361-366 doi: 10.15302/J-ENG-2015043

Abstract:

Based on the construction of the 8-inch fabrication line, advanced process technology of 8-inch wafergreat-leap forward technological development for the manufacturing of high-voltage IGBT from 6-inch to 8-

Keywords： insulated-gate bipolar transistor (IGBT) high power density trench gate 8-inch rail transportation

HTML PDF Collect

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 448-459 doi: 10.1007/s11684-020-0805-6

Abstract: FK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptoticidentified through immunoprecipitation–mass spectrometry-based proteomic analysis that the mitochondrial proteinprohibitin 1 (PHB1) specifically interacts with FKBP8.inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway, whereas the FKBP8Collectively, our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular

Keywords： prohibitin 1 FKBP8 mTOR cell proliferation cancer

HTML PDF Collect

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: Results showed that tumor necrosis factor α and interleukin 8 (IL-8) were vital in distinguishing patientsFinally, in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced

Keywords： acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker

HTML PDF Collect

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2, Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions systems biology omics plant immunity protein–protein interaction network

HTML PDF Collect

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: We have previously shown that interferon regulatory factor-8 (IRF8) and IRF4 serve as tumor suppressorsIn this study, we evaluated the expression of IRF4 and IRF8 and the JAK2V617F mutant allele burden inNegative correlations between the JAK2V617F allele burden and the expression of IRF8 (P <0.05)At 3 months, patients in the CR group showed high IRF4 and IRF8 expression compared with patients inOur data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype, which may

Keywords： myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia

HTML PDF Collect

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolismMoreover, FGF21 also plays important roles in some physiological processes, such as fasting and feedingClinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21This article concentrates on recent advances in our understanding of FGF21.

Keywords： FGF21 metabolism pharmacology physiology clinical relevance

HTML PDF Collect

Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:

Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 4, Pages 579-594 doi: 10.1007/s11705-018-1770-3

Abstract: The room temperature synthesis of ZIF-8 micro- and nano-particles was investigated using a mixed methanol-waterZIF-8 particles of good quality and high crystallinity were obtained.Response surface methodology was used to determine the effect of the synthesis conditions on the ZIF-8method to size-controlled synthesis of ZIF-8 particles.adsorption and the mid-sized ZIF-8 particles had the highest adsorption capacity.

Keywords： metal organic frameworks zeolitic imidazolate frameworks ZIF-8 response surface methodology Box Behnken